Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes.

@article{To2017ReversalOM,
  title={Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes.},
  author={Kenneth Kin-Wah To and Xu Wu and Chun Yin and Stella Chai and Sheng Yao and Onat Kadioglu and Thomas Efferth and Yang Ye and Ge Lin},
  journal={Journal of ethnopharmacology},
  year={2017},
  volume={203},
  pages={
          110-119
        }
}
ETHNOPHARMACOLOGICAL RELEVANCE Multidrug resistance (MDR) of cancer is often associated with the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), multidrug resistance-associated protein-1 (MRP-1) and breast cancer resistance protein (BCRP or ABCG2), in cancer cells, which facilitates the active efflux of a wide variety of chemotherapeutic drugs out of the cells. Marsdenia tenacissima is a traditional Chinese medicinal herb that has long been clinically… CONTINUE READING

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