Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.

Abstract

The purpose of our study was to test the hypothesis that 5-hydroxytryptamine (5-HT)(1A) receptor agonists counteract morphine-induced respiratory depression. Studies were conducted in anesthetized rats, and respiratory activity was monitored with diaphragm electromyography. Morphine was administered i.v. in doses that produce apnea. Once apnea was… (More)

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@article{Sahibzada2000ReversalOM, title={Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.}, author={Niaz Sahibzada and Margot Ferreira and Adam M Wasserman and Angelo M. Taveira-DaSilva and Richard A. Gillis}, journal={The Journal of pharmacology and experimental therapeutics}, year={2000}, volume={292 2}, pages={704-13} }