Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone.

@article{Bridges1982ReversalOM,
  title={Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone.},
  author={Robert S. Bridges and Charlotte Grimm},
  journal={Science},
  year={1982},
  volume={218 4568},
  pages={166-8}
}
Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the… CONTINUE READING

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