Reversal of mitochondrial defects before ischemia protects the aged heart.

  title={Reversal of mitochondrial defects before ischemia protects the aged heart.},
  author={Edward Joseph Lesnefsky and Dingchao He and Shadi Moghaddas and Charles L. Hoppel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 9},
Myocardial injury is increased in the aged heart during ischemia and reperfusion. Aging decreases oxidative metabolism in interfibrillar mitochondria (IFM) located between the myofibrils. We asked whether reversal of aging defects in IFM before ischemia would decrease injury in the aged heart following ischemia and reperfusion. Treatment with acetylcarnitine (AcCN) increases the activity of cytochrome oxidase in the aged heart. Aged (24 months) and adult (6 months) Fischer 344 rats were treated… CONTINUE READING


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