Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.

  title={Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.},
  author={E. H. Stet and Ronney A de Abreu and Jos P. M. B{\"o}kkerink and Lambert H. J. Lambooy and Trude M Vogels-Mentink and Jenneke J Keizer-Garritsen and Frans J.M. Trijbels},
  journal={Biochemical pharmacology},
  volume={49 1},
6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines. In this study prevention of MeSPuRib cytotoxicity by compounds of the purine salvage pathway was studied in Molt F4 human malignant T-lymphoblasts. Adenosine, adenine and inosine were able to prevent… CONTINUE READING
9 Citations
29 References
Similar Papers


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 29 references

JM , 6 - Mercaptopurine : cytotoxicity and biochemical pharmacology in human malignant T - lymphoblasts

  • DM Tidd, Paterson ARP
  • Biochem Pharmacol
  • 1993

Purification and properties in Molt F 4 , a human malignant T - lymphoblastic cell line

  • EH Stet, RA DeAbreu, +4 authors Trijbels GMF
  • Biochim Biophys Acta
  • 1993

The importance of methylthio - IMP for 6 - methylmercaptopurine ribo ­ nucleoside ( MeMPR ) cytotoxicity in Molt F 4 human malignant T - lymphoblasts

  • Bokkerink JPM, RA DeAbreu, +4 authors de Bruyn CHMM
  • Biochim Biophys Acta
  • 1993

Effects of methotrexate on purine and pyrimidine metabolism and cell - kinetic parameters in human malignant lymphoblasts of different lineages

  • JA Sokoloski, AC Sartorelli
  • Biochem Pharmacol
  • 1988

Damen incorporation into glycoproteins and dolichol - linked intermediates of sarcoma 180 cells by 6 - methyl ­ mercaptopurine ribonucleoside

  • Yen RCK, MA Becker
  • Int J Cancer
  • 1987

Mikanagi K, Relationship between phosphorylation and cytotoxicity of 2-chloroadenosine and 6-methylmercaptopurine riboside in human cells

  • E. H. STET
  • Biochim Biophys Acta
  • 1984

Similar Papers

Loading similar papers…