Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.

@article{Stet1995ReversalOM,
  title={Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.},
  author={E. H. Stet and Ronney A de Abreu and Jos P. M. B{\"o}kkerink and Lambert H. J. Lambooy and Trude M Vogels-Mentink and Jenneke J Keizer-Garritsen and Frans J.M. Trijbels},
  journal={Biochemical pharmacology},
  year={1995},
  volume={49 1},
  pages={49-56}
}
6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines. In this study prevention of MeSPuRib cytotoxicity by compounds of the purine salvage pathway was studied in Molt F4 human malignant T-lymphoblasts. Adenosine, adenine and inosine were able to prevent… CONTINUE READING
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