Reversal of long-term potentiation by inhibitors of haem oxygenase

  title={Reversal of long-term potentiation by inhibitors of haem oxygenase},
  author={Charles F. Stevens and Yanyan Wang},
EVIDENCE that carbon monoxide can serve as an intercellular messenger in brain1–3, a role much like that demonstrated for nitric oxide in various tissues4, prompted us to investigate whether carbon monoxide participates in long-term potentiation (LTP), the cellular mechanism that may underlie certain forms of learning and memory. Although LTP is triggered in the postsynaptic neuron, at least some fraction of LTP is expressed presynaptically as an increase in the quantity of neurotransmitter… CONTINUE READING
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