Reversal of learned helplessness by morphine in rats: involvement of a dopamine mediation.

@article{Besson1998ReversalOL,
  title={Reversal of learned helplessness by morphine in rats: involvement of a dopamine mediation.},
  author={Ang{\'e}lique Besson and Alain M. Privat and Alain Eschalier and Joseph Fialip},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={60 2},
  pages={519-25}
}
The aim of this study was to examine the role of dopamine neurotransmission in the effects of morphine in the learned helplessness paradigm in rats, a generally recognized model of depression. In this model, rats first exposed to inescapable shocks (stressed rats) exhibited an escape deficit in a subsequent shuttle-box test performed 48 h later for 3 consecutive days. The numbers of escape failures and intertrial crossings (motor activity during each intertrial interval) were recorded. Morphine… CONTINUE READING