Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine.

@article{Bakshi1998ReversalOI,
  title={Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine.},
  author={Vikram Bakshi and Neal R. Swerdlow and David L. Braff and Mark A. Geyer},
  journal={Biological psychiatry},
  year={1998},
  volume={43 6},
  pages={436-45}
}
BACKGROUND Prepulse inhibition (PPI) of startle provides an operational measure of sensorimotor gating in which a weak stimulus presented prior to a startling stimulus reduces the startle response. PPI deficits observed in schizophrenia patients can be modeled in rats by individual housing from weaning until adulthood. Deficits in PPI produced by isolation rearing can be reversed by antipsychotics. METHODS We evaluated the ability of Seroquel and olanzapine to reverse the isolation-induced… CONTINUE READING

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