Reversal of in vivo drug resistance by the transforming growth factor-beta inhibitor decorin.

@article{Teicher1997ReversalOI,
  title={Reversal of in vivo drug resistance by the transforming growth factor-beta inhibitor decorin.},
  author={Beverly A Teicher and Yoshihiko Maehara and Yoshihiro Kakeji and Gulshan Ara and Susan Riley Keyes and Josee F Wong and Roy S. Herbst},
  journal={International journal of cancer},
  year={1997},
  volume={71 1},
  pages={49-58}
}
Transforming growth factor-beta (TGF-beta) has been implicated in the in vivo resistance of the EMT-6/CTX and EMT-6/ CDDP murine mammary tumors. Both of these tumors have a higher number of intratumoral vessels than the EMT-6/ parent tumor. Animals bearing the resistant tumors have higher plasma levels of TGF-beta than animals bearing the parent tumors; however, upon treatment with cytotoxic therapies there is a greater rise in plasma TGF-beta levels in animals bearing the parent tumor than in… CONTINUE READING

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