Reversal of immunosuppression inducible through ultraviolet-exposed skin by in vivo anti-CD11b treatment.

@article{Hammerberg1996ReversalOI,
  title={Reversal of immunosuppression inducible through ultraviolet-exposed skin by in vivo anti-CD11b treatment.},
  author={Craig Hammerberg and N Duraiswamy and Kevin D. Cooper},
  journal={Journal of immunology},
  year={1996},
  volume={157 12},
  pages={5254-61}
}
In both human in vitro models and murine in vivo adoptive transfer studies, UV-induced class II MHC+ CD11b+ leukocytes that infiltrate the epidermis appear to mediate UV-induced immunosuppression. In the present study, their role is further probed using an anti-CD11b mAb (clone 5C6), which is effective in vivo in blocking CD11b+ monocyte/macrophage diapedesis into inflammatory lesions. A single exposure, low dose UV protocol (72 mJ/cm2) that resulted in tolerance only when dinitroflurobenzene… CONTINUE READING