Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis.

@article{Meyer1992ReversalOH,
  title={Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis.},
  author={J{\"o}rg-Uwe Meyer and Lillian D. Traber and Stuart Nelson and Christopher William Lentz and Hiroe Nakazawa and David N . Herndon and Hiroshi Noda and Daniel Lee Traber},
  journal={Journal of applied physiology},
  year={1992},
  volume={73 1},
  pages={324-8}
}
Septic shock is characterized by an increase in cardiac output and a fall in systemic vascular resistance index and mean arterial pressure. Endotoxin alters the smooth muscle function of blood vessels, probably by means of an increased production of the potent vasodilator nitric oxide (NO). The present study was accomplished to determine how the inhibition of NO synthesis influences cardiovascular performance in an ovine model of hyperdynamic endotoxemia. Endotoxemia was induced in five range… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…