Reversal of hippocampal neuronal maturation by serotonergic antidepressants.

  title={Reversal of hippocampal neuronal maturation by serotonergic antidepressants.},
  author={Katsunori Kobayashi and Yumiko Ikeda and Atsushi Sakai and Nobuyuki Yamasaki and Eisuke Haneda and Tsuyoshi Miyakawa and Hidenori Suzuki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 18},
Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety disorders, and increasing evidence suggests potential use of these drugs beyond current antidepressant therapeutics. Facilitation of adult neurogenesis in the hippocampal dentate gyrus has been suggested to be a candidate mechanism of action of antidepressant drugs, but this mechanism may be only one of the broad effects of antidepressants. Here we show a distinct unique action of the serotonergic antidepressant… CONTINUE READING
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