Reversal of haloperidol-induced orofacial dyskinesia by Murraya koenigii leaves in experimental animals.

@article{Patil2012ReversalOH,
  title={Reversal of haloperidol-induced orofacial dyskinesia by Murraya koenigii leaves in experimental animals.},
  author={Rupali Arun Patil and Yogesh Ashok Hiray and Sandesh Shinde and Padmaja Mukund Langade},
  journal={Pharmaceutical biology},
  year={2012},
  volume={50 6},
  pages={691-7}
}
CONTEXT Orofacial dyskinesia (OD) is a late complication of prolonged neuroleptic treatment characterized by involuntary movements of the oral region. Chronic treatment with neuroleptics leads to development of vacuous chewing movements (VCMs). VCMs in rats are widely accepted as an animal model of OD. OBJECTIVE To study the effect of Murraya koenigii L. (Rutaceae) leaves on haloperidol-induced OD. MATERIALS AND METHODS Effect of alcohol extract of M. koenigii leaves (EEMK) and its alkaloid… CONTINUE READING