Reversal of granulocyte adherence to nylon fibers using local anesthetic agents: possible application to filtration leukapheresis.

@article{Schiffer1977ReversalOG,
  title={Reversal of granulocyte adherence to nylon fibers using local anesthetic agents: possible application to filtration leukapheresis.},
  author={Charles A Schiffer and F. T. Sanel and Vincent B Young and Joseph Aisner},
  journal={Blood},
  year={1977},
  volume={50 2},
  pages={
          213-25
        }
}
The effects of the cationic anesthetic agents tetracaine and lidocaine on granulocyte function, morphology, and adherence to nylon fibers were studied in an attempt to improve current methods of granulocyte collection by filtration leukapheresis (FL). When dissolved in acid-citrate-dextrose (ACD) plasma, these drugs significantly increased granulocyte elution from the fibers in a dose-related fashion. Granulocytes exposed to tetracaine and lidocaine remained more than 95% viable, retained… CONTINUE READING

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