Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats.

@article{Srinivasan2004ReversalOG,
  title={Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats.},
  author={K. Srinivasan and P. Patole and C. Kaul and P. Ramarao},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2004},
  volume={26 5},
  pages={
          327-33
        }
}
The present study was undertaken to determine the effect of pioglitazone (3, 10 and 30 mg/kg p.o.), an insulin sensitizer, on glucose intolerance in high fat diet- (HFD) fed rats (a nongenetic model of insulin resistance). In addition, the effect of pioglitazone (3, 10 and 30 mg/kg p.o.) on diet-induced changes in body weight, plasma glucose, insulin, triglyceride and total cholesterol levels were also determined. The feeding of HFD for 4 weeks produced a significant increase in body weight… Expand
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