Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.

  title={Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.},
  author={Hagai Bergman and Thomas Wichmann and Mahlon R. Delong},
  volume={249 4975},
Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in the substantia nigra, the resulting alterations in activity in the basal ganglia responsible for parkinsonian motor deficits are still poorly characterized. Recently, increased activity in the subthalamic nucleus has been implicated in the motor abnormalities. To test this hypothesis, the effects of lesions of the subthalamic nucleus were evaluated in monkeys rendered parkinsonian by treatment with 1… CONTINUE READING
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