Reversal of endothelin-induced vasoconstriction by endothelium-dependent and -independent vasodilators in isolated hearts and vascular rings.

@article{Stowe1997ReversalOE,
  title={Reversal of endothelin-induced vasoconstriction by endothelium-dependent and -independent vasodilators in isolated hearts and vascular rings.},
  author={David F. Stowe and Walter O'Brien and Dehua Chang and Christian Knop and John P. Kampine},
  journal={Journal of cardiovascular pharmacology},
  year={1997},
  volume={29 6},
  pages={747-54}
}
Endothelin (ET-1) is a potent endogenous vasoconstrictor. Several factors increase ET-1 release in vitro and ET-1 levels increase in vivo in situations that damage blood vessels. The aim of this study was to test the activity of several differently acting vasodilator drugs on reversing or attenuating the vasoconstrictor effects of exogenously administered ET-1 in isolated guinea-pig hearts, in isolated rings with intact endothelium from canine middle cerebral and basilar arteries, and from… CONTINUE READING