Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation.

@article{Becker1986ReversalOD,
  title={Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation.},
  author={Lewis C. Becker and Joseph H. Levine and Anthony Dipaula and Thomas Guarnieri and Thomas R Aversano},
  journal={Journal of the American College of Cardiology},
  year={1986},
  volume={7 3},
  pages={580-9}
}
After brief coronary occlusions, myocardium may become "stunned," exhibiting prolonged depression of function despite the absence of necrosis. Because of the accompanying decline in adenosine triphosphate and adenine nucleotide precursors, a deficiency of energy supply has been proposed as the basis for postischemic dysfunction. This study examined whether sufficient functional and metabolic reserve exists in stunned myocardium to sustain a prolonged, maximal inotropic response to epinephrine… CONTINUE READING
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