Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function.

@article{Chen2001ReversalOD,
  title={Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function.},
  author={Z S Chen and Shunji Aoki and Masaharu Komatsu and Koji Ueda and Tomoyuki Sumizawa and Tatsuhiko Furukawa and Hiroshi Okumura and Xiao Qin Ren and Martin G Belinsky and K Lee and Gary D. Kruh and Motohiro Kobayashi and Shin-ichi Akiyama},
  journal={International journal of cancer},
  year={2001},
  volume={93 1},
  pages={107-13}
}
We previously isolated agosterol A (AG-A) from a marine Spongia sp. and found that it completely reversed colchicine resistance in P-glycoprotein (Pgp)-over-expressing KB-C2 cells and vincristine resistance in multidrug-resistance protein (MRP)1-over-expressing CV60 cells. However, a tri-deacetylated derivative of AG-A (IAG-A) showed almost no activity in reversing Pgp- or MRP1-mediated drug resistance. In this study, we examined the mechanisms by which AG-A reverses MRP1-mediated drug… CONTINUE READING