Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

@article{Savage2006ReversalOD,
  title={Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.},
  author={David B Savage and Cheol Soo Choi and Varman T Samuel and Z X Liu and Dongyan Zhang and Amy Wang and Xian-man Zhang and Gary W. Cline and Xing Xian Yu and John G. Geisler and Sanjay Bhanot and Brett P. Monia and Gerald I Shulman},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 3},
  pages={817-24}
}
Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads to hepatic insulin resistance. Malonyl-CoA, generated by acetyl-CoA carboxylases 1 and 2 (Acc1 and Acc2), is a key regulator of both mitochondrial fatty acid oxidation and fat synthesis. We used a diet-induced rat model of nonalcoholic fatty liver disease (NAFLD) and hepatic insulin resistance to explore the impact of suppressing Acc1, Acc2, or both Acc1 and Acc2 on hepatic lipid levels and insulin… CONTINUE READING
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