Reversal of diabetic nephropathy: lessons from pancreas transplantation.

  title={Reversal of diabetic nephropathy: lessons from pancreas transplantation.},
  author={Paola Fioretto and Michael G. Mauer},
  journal={Journal of nephrology},
  volume={25 1},
Pancreas transplantation is the only therapeutic intervention able to achieve and maintain long-term euglycemia, without risks of hypoglycemia; this makes it possible to test the impact of normoglycemia in the different stages of diabetic nephropathy. Pancreas and islet transplantation in animal models prevent the development of diabetic nephropathy lesions and ameliorate or reverse established glomerular lesions. In type 1 diabetic patients, pancreas transplantation, performed simultaneously… CONTINUE READING
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