Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

@article{Rezania2014ReversalOD,
  title={Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells},
  author={Alireza Rezania and J. Bruin and P. Arora and A. Rubin and Irina Batushansky and A. Asadi and Shannon M O'Dwyer and Nina Quiskamp and M. Mojibian and T. Albrecht and Y. Yang and J. D. Johnson and T. Kieffer},
  journal={Nature Biotechnology},
  year={2014},
  volume={32},
  pages={1121-1133}
}
  • Alireza Rezania, J. Bruin, +10 authors T. Kieffer
  • Published 2014
  • Biology, Medicine
  • Nature Biotechnology
  • Transplantation of pancreatic progenitors or insulin-secreting cells derived from human embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a seven-stage protocol that efficiently converts hESCs into insulin-producing cells. Stage (S) 7 cells expressed key markers of mature pancreatic beta cells, including MAFA, and displayed glucose-stimulated insulin secretion similar to that of human islets during static incubations in vitro. Additional characterization… CONTINUE READING
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    References

    SHOWING 1-10 OF 62 REFERENCES
    Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
    • 1,664
    • PDF
    Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.
    • 80
    A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
    • 431
    • PDF