Reversal of diabetes by the creation of neo-islet tissues into a subcutaneous site using islet cell sheets.

@article{Saito2011ReversalOD,
  title={Reversal of diabetes by the creation of neo-islet tissues into a subcutaneous site using islet cell sheets.},
  author={Takahiro Saito and Kazuo Ohashi and Rie Utoh and Hirofumi Shimizu and Kazuya Ise and Hiroyuki Suzuki and Masayuki Yamato and T. Okano and Mitsukazu Gotoh},
  journal={Transplantation},
  year={2011},
  volume={92 11},
  pages={1231-6}
}
BACKGROUND There remains a paucity of therapeutic approaches to completely treat diabetes mellitus. This study was designed to develop a dispersed islet cell-based tissue engineering approach to engineer functional neo-islet tissues in the absence of traditional bioabsorbable scaffold matrices. METHODS Specialized coated plastic dishes were prepared by covalently immobilizing a temperature-responsive polymer, poly(N-isopropylacrylamide), onto the plastic followed by coating with laminin-5… CONTINUE READING

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