Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica.

@article{Sangeetha2013ReversalOD,
  title={Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica.},
  author={Kadapakkam Nandabalan Sangeetha and Koppula Shilpa and P Jyothi Kumari and Baddireddi Subhadra Lakshmi},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2013},
  volume={20 3-4},
  pages={213-20}
}
AIM The present study investigates the efficacy of Mangifera indica ethyl acetate extract (MIEE) and its bioactive compound, 3β-taraxerol in the reversal of dexamethasone (DEX) induced insulin resistance in 3T3L1 adipocytes. MAIN METHODS MIEE and 3β-taraxerol were evaluated for their ability to restore impaired glucose uptake and, expression of molecular markers in the insulin signaling pathway induced by DEX in 3T3L1 adipocytes using 2-deoxy-D-[1-(3)H] glucose uptake assay and ELISA. KEY… CONTINUE READING