Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting

@article{Broberg2009ReversalOC,
  title={Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting},
  author={Brian Villumsen Broberg and Birte Yding Glenth{\o}j and Rebecca dos Santos Dias and Dorrit Bjerg Larsen and Christina Kurre Olsen},
  journal={Psychopharmacology},
  year={2009},
  volume={206},
  pages={631-640}
}
RationaleTherapies treating cognitive impairments in schizophrenia especially deficits in executive functioning are not available at present.ObjectiveThe current study evaluated the effect of ampakine CX516 in reversing deficits in executive functioning as represented in two animal models of schizophrenia and assessed by a rodent analog of the intradimensional–extradimensional (ID–ED) attentional set-shifting task. The second generation antipsychotic, sertindole, provided further validation of… CONTINUE READING
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