Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol

@article{Cit2012ReversalOC,
  title={Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol},
  author={Maria do Carmo de Oliveira Cit{\'o} and Francisca Charliane Carlos da Silva and Maria Izabel Gomes Silva and Brinell Arcanjo Moura and Francisca Cl{\'e}a Florenço de Sousa},
  journal={Behavioural Brain Research},
  year={2012},
  volume={231},
  pages={116-123}
}
Cocaine is used worldwide and considered a public health problem. Relapse from addiction is one of the difficulties faced by cocaine users, and in most cases according to the period of abstinence, users may present symptoms such as anxiety or depression. To evaluate the anxiety-like behavior induced by different periods, rats were treated for 7 days with cocaine 20 mg/kg, i.p., and 24 h, 7 and 21 days after drug withdrawal were submitted to the elevated plus maze (EPM) and the open field (OF… CONTINUE READING

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