Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II.

@article{Luo2008ReversalOC,
  title={Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II.},
  author={Fang Lin Luo and Cheng Yang and Yan Chen and Pradeep R. Shukla and Lei Tang and Lili X Wang and Zaijie Jim Wang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 1},
  pages={267-75}
}
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a major protein kinase that is capable of regulating the activities of many ion channels and receptors. In the present study, the role of CaMKII in the complete Freund's adjuvant (CFA)-induced inflammatory pain was investigated. Intraplantarly injected CFA was found to induce spinal activity of CaMKII (phosphorylated CaMKII), which was blocked by KN93 [[2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N… CONTINUE READING

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