Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats.

@article{Miri2001ReversalOC,
  title={Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats.},
  author={G Miri{\'c} and Catherine Dallemagne and Zoltan H. Endre and Solomon B. Margolin and Stephen M. Taylor and Lindsay Brown},
  journal={British journal of pharmacology},
  year={2001},
  volume={133 5},
  pages={
          687-94
        }
}
Fibrosis leads to chronic impairment of cardiac and renal function and thus reversal of existing fibrosis may improve function and survival. This project has determined whether pirfenidone, a new antifibrotic compound, and spironolactone, an aldosterone antagonist, reverse both deposition of the major extracellular matrix proteins, collagen and fibronectin, and functional changes in the streptozotocin(STZ)-diabetic rat. Streptozotocin (65 mg kg(-1) i.v.)-treated rats given pirfenidone (5-methyl… CONTINUE READING
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