Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment

  title={Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment},
  author={Yigal Gat and Michael Gornish and Mois{\'e}s Heiblum and S. Joshua},
The prostate is an androgen-regulated exocrine gland producing over 30% of the noncellular components of the semen and promoting optimal conditions for survival and motility of sperm in the vagina. [] Key Method We have treated 28 BPH patients using a technique that restores normal pressure in the venous drainage in the male reproductive system. The back-pressure and the back-flow of blood from the testicular to the prostate drainage system were eliminated and, consequently, a rapid reduction in prostate…
Prostate cancer: a newly discovered route for testosterone to reach the prostate
It is concluded that pathological flow of FT from the testes directly to the prostate in an extremely high concentration via the testicular‐prostate venous drainage systems was identified may explain the mechanism for the development of PCa and is suggested for eradication of localised, androgen‐sensitive, PCa cells.
Treatment of benign prostatic hyperplasia by occlusion of the impaired urogenital venous system - first experience.
Interventional occlusion of the spermatic veins in patients with BPH is a feasible outpatient procedure with a low complication rate and Intermediate results are satisfactory.
Qianliening capsule treats benign prostatic hyperplasia via suppression of the EGF/STAT3 signaling pathway
Results suggest that suppression of the EGF/STAT3 pathway may be one of the mechanisms by which Qianliening capsule treats BPH.
Benign prostatic hypertrophy
Low-grade chronic elevations of intra-abdominal pressure would provide the opportunity for the development of increased pressure in the internal spermatic veins and possibly for other systems also, which could better explain the epidemiological findings that BPH, hypogonadism and obesity are frequently seen together.
Benign prostatic hyperplasia: the hypogonadal-obesity-prostate connection.
Benign Prostatic Hyperplasia: Long‐term follow‐up of prostate volume reduction after sclerotherapy of the internal spermatic veins
It is concluded that effective treatment of varicocele restores normal supply of testosterone to the prostate solely via its arterial supply, resulting in significant decrease of prostate volume and prostatic symptoms.
It was found that sex hormonal disturbances associated with increase age of the person was implicated in the pathogenesis of BPH, and serum levels of both estrogen and testosterone were evaluated and estrogen receptors were estimated by immunohistochemisitry.
Vitamin K: the missing link to prostate health.
Role of varicocele sclerotherapy in the management of benign prostatic hyperplasia and its associated lower urinary tract symptoms (pilot study)
Varicoceles sclerotherapy can be employed to resolve the testicular venous insufficiency and mitigate the severity of the prostatic-related urological symptoms in middle-aged and elderly men, so varicocele can be considered a confounding variable in the development of the prostate-related lower urinary tract symptoms.
Treatment of Benign Prostatic Hyperplasia by Occlusion of the Impaired Urogenital Venous System – First Experience Behandlung der benignen Prostatahyperplasie durch Embolisation des insuffizienten urogenitalen Venensystems – eine Zwischenbilanz
Venous embolization in patients with BPH is a feasible outpatient procedure that shows satisfactory intermediate result with good symptom relief and medium and long-term results need to be further evaluated.


Nonsurgical treatment of prostatic hyperplasia.
It is suggested that BPH may be multifactorial and require combined therapy and androgen would certainly appear to be necessary, but perhaps not sufficient, for the pathogenesis of this disorder.
The association of benign prostatic hyperplasia and cancer of the prostate
It is important to exclude cancer in patients presenting with symptoms of bladder outlet obstruction presumably due to BPH, and digital rectal examination and, at least in high‐risk patients, serum prostate specific antigen (PSA) determination should be employed in patients with elevated PSA levels.
Persistent intraprostatic androgen concentrations after medical castration in healthy men.
Despite a 94% decrease in serum T with medical castration, intraprostatic T and dihydrotestosterone levels remained 20-30% of control values, and prostate cell proliferation, apoptosis, and androgen-regulated protein expression were unaffected, highlighting the importance of assessing tissue hormone levels.
Serum steroids in relation to benign prostatic hyperplasia.
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Varicocele, hypoxia and male infertility. Fluid Mechanics analysis of the impaired testicular venous drainage system.
The internal spermatic veins by venography was investigated to understand testicular damage due to varicocele and found thermography alone or combined with ultrasonography with special attention to the bilaterality of the disease are the best non-invasive tools for its detection.
Nonsurgical treatment of prostatic hyperplasia
It is now possible to quantify prostate size and function with reliable new techniques and to utilize androgen withdrawal studies to test the validity of the DHT theory.
Is varicocele prevalence increasing with age?
It is found that the prevalence of varicocele increases with age with a rise of about 10% for each decade of life with the incidence reaching 75% in the eight decade oflife.
The role of the androgen receptor in the development of prostatic hyperplasia and prostate cancer
  • B. Chatterjee
  • Biology, Medicine
    Molecular and Cellular Biochemistry
  • 2004
Persistence of signaling by the wild-type AR in therapy-resistant tumors is due to the increased receptor activity caused by cross talk of AR with multiple intracellular signaling cascades, especially the growth factor activated MAP kinase/ERK and PI3 Kinase/Akt pathways.
The development of androgenindependent prostate cancer
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  • 2001