Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine.

@article{Patel2011ReversalOA,
  title={Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine.},
  author={Nishith N B Patel and Hua Lin and Tibor T{\'o}th and Gavin I. Welsh and Ceri Jones and Paramita Ray and Simon C. Satchell and Philippa A. Sleeman and Gianni Angelini and Gavin J Murphy},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={301 3},
  pages={F605-14}
}
Anemia during cardiopulmonary bypass (CPB) is strongly associated with acute kidney injury in clinical studies; however, reversal of anemia with red blood cell (RBC) transfusions is associated with further renal injury. To understand this paradox, we evaluated the effects of reversal of anemia during CPB with allogenic RBC transfusion in a novel large-animal model of post-cardiac surgery acute kidney injury with significant homology to that observed in cardiac surgery patients. Adult pigs… CONTINUE READING

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