Reversal of amphetamine-induced circling preference in trained circling rats.

@article{Yamamoto1984ReversalOA,
  title={Reversal of amphetamine-induced circling preference in trained circling rats.},
  author={Bryan K. Yamamoto and Curt R. Freed},
  journal={Life sciences},
  year={1984},
  volume={34 7},
  pages={
          675-82
        }
}
Others have shown that amphetamine given to normal rats causes turning in a particular, preferred direction in most animals. We have studied the effect of training on amphetamine-induced behavioral and biochemical asymmetries in male Sprague-Dawley rats. Water deprived animals were trained to circle either in the same or opposite direction to their intrinsic bias using a sucrose water reward. Acquisition of the learned circling behavior was independent of turning preference and all animals were… CONTINUE READING