Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.

@article{Liu2003ReversalOA,
  title={Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.},
  author={Ruolan Liu and Ingrid Y-C Liu and Xiaoning Bi and Richard F. Thompson and Susan R. Doctrow and Bernard Malfroy and Michel Baudry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 14},
  pages={8526-31}
}
Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for preserving… CONTINUE READING