Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2.

@article{Karczewski2010ReversalOA,
  title={Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2.},
  author={Jerzy Karczewski and R. H. Spencer and Victor M. Garsky and Annie Liang and Michael D. Leitl and Matthew J Cato and Sean Peter Cook and Stefanie Kane and Mark O. Urban},
  journal={British journal of pharmacology},
  year={2010},
  volume={161 4},
  pages={950-60}
}
BACKGROUND AND PURPOSE Inflammatory pain is triggered by activation of pathways leading to the release of mediators such as bradykinin, prostaglandins, interleukins, ATP, growth factors and protons that sensitize peripheral nociceptors. The activation of acid-sensitive ion channels (ASICs) may have particular relevance in the development and maintenance of inflammatory pain. ASIC3 is of particular interest due to its restricted tissue distribution in the nociceptive primary afferent fibres and… CONTINUE READING
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