Reversal of Tumor-induced Immunosuppression by TGF-β Inhibitors

  title={Reversal of Tumor-induced Immunosuppression by TGF-β Inhibitors},
  author={Slawomir M. Wojtowicz-Praga},
  journal={Investigational New Drugs},
The immune system is responsible for the early detection and destruction of newly transformed malignant cells. Some transformed cells become immunologically invisible by passive avoidance of immune surveillance (i.e., when tumor cells are immunologically indistinguishable from normal cells). Other transformed cells actively secrete cytokines that effectively blind the immune system to the presence of abnormal antigens on the tumor cell surface. Transforming growth factor-β (“TGF-β”), which is… CONTINUE READING