Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's - derived fibroblasts

Abstract

BACKGROUND Myofibroblasts, a derived subset of fibroblasts especially important in scar formation and wound contraction, have been found at elevated levels in affected Dupuytren's tissues. Transformation of fibroblasts to myofibroblasts is characterized by expression of alpha- smooth muscle actin (α-SMA) and increased production of extracellular matrix (ECM… (More)
DOI: 10.1186/1471-2474-12-113

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@inproceedings{Satish2011ReversalOT, title={Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's - derived fibroblasts}, author={L. P. K. Satish and Phillip H. Gallo and Mark E. Baratz and Sandra Johnson and Sandeep Kathju}, booktitle={BMC musculoskeletal disorders}, year={2011} }