Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid

@article{Liu2019ReversalOT,
  title={Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid},
  author={Yukun Liu and Shuyun Xu and Tingjian Zu and Feng Ling Li and Shengbo Sang and Cynthia Liu and Yang An and Bobin Mi and Dennis Paul Orgill and George R F Murphy and Christine G Lian},
  journal={Laboratory Investigation},
  year={2019},
  pages={1-10}
}
Hypoxia resulting in hypoxia-inducible factor-1 alpha (HIF-1α) induction is known to drive scar formation during cutaneous wound healing, and may be responsible for excessive fibrosis inherent to hypertrophic scars and keloids. Because epigenetic pathways play an important role in regulation of fibrosing processes, we evaluated patient scars for DNA hydroxymethylation (5-hydroxymethylcytosine; 5-hmC) status and documented a significant decrease in scar fibroblasts. To test this finding in vitro… CONTINUE READING
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