Reversal of Selective Toxicity of (−)-α-Lipoic Acid by Thiamine in Thiamine-deficient Rats

@article{Gal1965ReversalOS,
  title={Reversal of Selective Toxicity of (−)-$\alpha$-Lipoic Acid by Thiamine in Thiamine-deficient Rats},
  author={EMERY M. Gal},
  journal={Nature},
  year={1965},
  volume={207},
  pages={535-535}
}
  • E. Gal
  • Published 31 July 1965
  • Chemistry
  • Nature
INTRAPERITONEAL injection of (±)-α-lipoic acid has been reported to be toxic to thiamine-deficient rats1. Development of the toxic effect was prevented by simultaneous injection of 100 µg of thiamine hydrochloride. It was also noticed that (±)-α-lipoic acid, unlike neopyrithiamine, had no effect on thiamine excretion. The toxicity of (±)-α-lipoic acid to thiamine-deficient rats therefore could not be related to the depletion of the thiamine reserves present in the organs of thiamine-deficient… Expand
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    References

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    Studies on the in vivo metabolism of lipoic acid. 1. The fate of DL-lipoic acid-S35 in normal and thiamine-deficient rats.
    TLDR
    Intraperitoneal injection of dl -lipoic acid was toxic to deficient animals but, unlike neopyrithiamine, had no effect on thiamine excretion. Expand