Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate: A Randomized, Placebo-Controlled, Crossover Study in Healthy Subjects

@article{Eerenberg2011ReversalOR,
  title={Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate: A Randomized, Placebo-Controlled, Crossover Study in Healthy Subjects},
  author={Elise S. Eerenberg and Pieter Willem Kamphuisen and Meertien K. Sijpkens and Joost C. M. Meijers and Harry R. Buller and Marcel Levi},
  journal={Circulation},
  year={2011},
  volume={124},
  pages={1573–1579}
}
Background— Rivaroxaban and dabigatran are new oral anticoagulants that specifically inhibit factor Xa and thrombin, respectively. Clinical studies on the prevention and treatment of venous and arterial thromboembolism show promising results. A major disadvantage of these anticoagulants is the absence of an antidote in case of serious bleeding or when an emergency intervention needs immediate correction of coagulation. This study evaluated the potential of prothrombin complex concentrate (PCC… 

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Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate : A Randomized , Placebo-Controlled , Crossover Study in Healthy Subjects ”
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