Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.

@article{Chen2004ReversalOP,
  title={Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.},
  author={Li-ming Chen and Yong-ju Liang and Ji-wu Ruan and Yihong Ding and Xiu-wen Wang and Zhi Shi and Lian-Quan Gu and Xiao-ping Yang and Liwu Fu},
  journal={The Journal of pharmacy and pharmacology},
  year={2004},
  volume={56 8},
  pages={1061-6}
}
Overexpression of P-glycoprotein (P-gp) by tumours results in multidrug resistance (MDR) to structurally and functionally unrelated chemotherapeutic drugs. Combined therapy with MDR-related cytotoxins and MDR modulators is a promising strategy to overcome clinical MDR. This study was performed to explore the MDR reversal activity of a novel compound 2-[4-(2-pyridin-2-yl-vinyl) phenyl]-4,5-bis-(4-N,N-diethylaminophenyl)-1(H)-imidazole (FG020318) in-vitro and in-vivo. Tetrazolium (MTT) assay was… CONTINUE READING