Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519.

@article{Che2002ReversalOP,
  title={Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519.},
  author={X M Che and Yuichi Nakajima and Tomoyuki Sumizawa and Ryuji Ikeda and X Q Ren and Chun-Lei Zheng and Motoi Mukai and Tatsuhiko Furukawa and Misako Haraguchi and Hui Gao and Yoshikazu Sugimoto and Shin-ichi Akiyama},
  journal={Cancer letters},
  year={2002},
  volume={187 1-2},
  pages={111-9}
}
A newly synthesized 1,4-benzothiazipine derivate, 4-[3-(4-benzylpiperidin-1-yl) propionyl]-7-methoxy-2,3,4,5-tetrahydro-1, 4-benzothiazepine monohydrochloride (JTV-519) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP1) mediated multidrug resistance (MDR) in K562/MDR and KB/MRP cells, respectively. JTV-519 at 3 microM reversed the resistance of K562/MDR cells to vincristine (VCR), taxol, etoposide (VP16), adriamycin (ADM) and actinomycin D… CONTINUE READING