Reversal of P-glycoprotein-mediated multidrug resistance by the novel tetrandrine derivative W6.

@article{Sun2015ReversalOP,
  title={Reversal of P-glycoprotein-mediated multidrug resistance by the novel tetrandrine derivative W6.},
  author={Hua Sun and Xiaodong Liu and Qian Liu and Feng-peng Wang and Xiu-qi Bao and Dan Zhang},
  journal={Journal of Asian natural products research},
  year={2015},
  volume={17 6},
  pages={638-48}
}
Overexpression of ATP-dependent efflux pump P-glycoprotein (P-gp) is the main cause of multidrug resistance (MDR) and chemotherapy failure in cancer treatment. Inhibition of P-gp-mediated drug efflux is an effective way to overcome cancer drug resistance. The present study investigated the reversal effect of the novel tetrandrine derivative W6 on P-gp-mediated MDR. KBv200, MCF-7/adr and their parental sensitive cell lines KB, MCF-7 were used for reversal study. The intracellular accumulation… CONTINUE READING