Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.

@article{Zhang2009ReversalEO,
  title={Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.},
  author={Ye Zhang and Xiu-juan Qu and Yun-Peng Liu and Xiang-Hong Yang and Ke-zuo Hou and Yue-e Teng and Jing-dong Zhang},
  journal={Ai zheng = Aizheng = Chinese journal of cancer},
  year={2009},
  volume={28 2},
  pages={
          97-9
        }
}
BACKGROUND AND OBJECTIVE Phosphatidylinositol-3-kinase/protein kinase B (PI3-K/Akt) signaling pathway plays an important role in cell survival. This study was to explore the reversal effect of PI3-K inhibitor LY294002 on p-glycoprotein (P-gp)-mediated multidrug resistance in human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR. METHODS The cells were divided into simple drug-treated groups and LY294002 pretreated groups: the former groups received treatment of… CONTINUE READING