Reversal by β-funaltrexamine and 16-methyl cyprenorphine of the antinociceptive effects of opioid agonists in the mouse and guinea-pig

@article{Hayes1988ReversalB,
  title={Reversal by $\beta$-funaltrexamine and 16-methyl cyprenorphine of the antinociceptive effects of opioid agonists in the mouse and guinea-pig},
  author={Ann G. Hayes and Phillip John Birch},
  journal={Neuropharmacology},
  year={1988},
  volume={27},
  pages={813-816}
}
Abstract The present study compared the effects of two opioid antagonists, β-funaltrexamine (β-FNA) and 16-methyl cyprenorphine (RX8008M) on the antinociception produced by a range of opioid agonists in the abdominal constriction test in the mouse and the paw pressure test in the guinea-pig. Both antagonists produced large shifts in the dose-response curves to the μ-agonists, morphine and fentanyl, confirming their μ-antagonist activity. Neither antagonist produced any antagonism of the… Expand
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