Reversal Learning and Associative Memory Impairments in a BACHD Rat Model for Huntington Disease

@inproceedings{Abada2013ReversalLA,
  title={Reversal Learning and Associative Memory Impairments in a BACHD Rat Model for Huntington Disease},
  author={Yah-se K. Abada and Huu Phuc Nguyen and Bart Ellenbroek and Rudy Schreiber},
  booktitle={PloS one},
  year={2013}
}
Chorea and psychiatric symptoms are hallmarks of Huntington disease (HD), a neurodegenerative disorder, genetically characterized by the presence of expanded CAG repeats (>35) in the Huntingtin (HTT) gene. HD patients present psychiatric symptoms prior to the onset of motor symptoms and we recently found a similar emergence of non motor and motor deficits in BACHD rats carrying the human full length mutated HTT (97 CAG-CAA repeats). We evaluated cognitive performance in reversal learning and… CONTINUE READING

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Assessment of Motor, sensory motor gating and Recognition memory in a novel full-length rat model for Huntington disease. doi: 10.1371/journal.pone.0068584

  • YS Abada, HP Nguyen, R Schreiber, B Ellenbroek
  • 2013
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