Revealing the world of RNA interference

@article{Mello2004RevealingTW,
  title={Revealing the world of RNA interference},
  author={Craig C. Mello and Darryl Conte},
  journal={Nature},
  year={2004},
  volume={431},
  pages={338-342}
}
The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena. 
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( siRNAs )

  • C. A. Sledz, M. Holko, M. J. de Veer, R. H. Silverman, B. R. Williams
  • 2004

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