Revealing the hidden functional diversity of an enzyme family.

@article{Bastard2014RevealingTH,
  title={Revealing the hidden functional diversity of an enzyme family.},
  author={Karine Bastard and Adam Alexander Thil Smith and Carine Vergne-Vaxelaire and Alain Perret and Anne Zaparucha and Raquel Cardoso de Melo-Minardi and Aline Mariage and Magali Boutard and Adrien Debard and Christophe Lechaplais and Christine Pell{\'e} and Virginie Pellouin and Nadia Perchat and Jean-Louis Petit and Annett Kreimeyer and Claudine M{\'e}digue and Jean Weissenbach and François Artiguenave and V{\'e}ronique de Berardinis and David Vallenet and Marcel Salanoubat},
  journal={Nature chemical biology},
  year={2014},
  volume={10 1},
  pages={42-9}
}
Millions of protein database entries are not assigned reliable functions, preventing the full understanding of chemical diversity in living organisms. Here, we describe an integrated strategy for the discovery of various enzymatic activities catalyzed within protein families of unknown or little known function. This approach relies on the definition of a generic reaction conserved within the family, high-throughput enzymatic screening on representatives, structural and modeling investigations… CONTINUE READING
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