Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells.

Abstract

Glaucium flavum (G. flavum) is a plant from the Papaveraceae family native to Algeria where it is used in local traditional medicine to treat warts. G. flavum root crude alkaloid extract inhibited breast cancer cell proliferation and induced G2/M phase cycle arrest and apoptosis without affecting normal cells, which is a highly awaited feature of potential anti-cancer agents. G. flavum significantly reduced growth and vascularization of human glioma tumors on chicken chorioallantoic membrane (CAM) in vivo. The chromatographic profile of the dichloromethane extract of G. flavum root showed the presence of different constituents including the isoquinoline alkaloid protopine, as the major compound. We report for the first time that G. flavum extract may represent a new promising agent for cancer chemotherapy.

DOI: 10.1016/j.phymed.2013.06.007

Cite this paper

@article{Bournine2013RevealingTA, title={Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells.}, author={Lamine Bournine and Sihem Bensalem and Paul Peixoto and Arnaud Gonzalez and Fadila Maiza-Benabdesselam and Fatiha Bedjou and Jean-N{\"{o}el Wauters and Monique Tits and Michel Fr{\'e}d{\'e}rich and Vincent Castronovo and Akeila Bellahc{\'e}ne}, journal={Phytomedicine : international journal of phytotherapy and phytopharmacology}, year={2013}, volume={20 13}, pages={1211-8} }