Revealing global regulatory perturbations across human cancers.

@article{Goodarzi2009RevealingGR,
  title={Revealing global regulatory perturbations across human cancers.},
  author={H. Ghasemi Goodarzi and Olivier Elemento and Saeed Tavazoie},
  journal={Molecular cell},
  year={2009},
  volume={36 5},
  pages={
          900-11
        }
}
The discovery of pathways and regulatory networks whose perturbation contributes to neoplastic transformation remains a fundamental challenge for cancer biology. We show that such pathway perturbations, and the cis-regulatory elements through which they operate, can be efficiently extracted from global gene expression profiles. Our approach utilizes information-theoretic analysis of expression levels, pathways, and genomic sequences. Analysis across a diverse set of human cancers reveals the… CONTINUE READING
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