Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform.

@article{Pan2004RevealingGR,
  title={Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform.},
  author={Qun Pan and Ofer Shai and Christine Misquitta and Wen Zhang and Arneet L. Saltzman and Naveed Mohammad and Tomas Babak and Henry E. Siu and Timothy R. Hughes and Quaid Morris and Brendan J. Frey and Benjamin J. Blencowe},
  journal={Molecular cell},
  year={2004},
  volume={16 6},
  pages={929-41}
}
We describe the application of a microarray platform, which combines information from exon body and splice-junction probes, to perform a quantitative analysis of tissue-specific alternative splicing (AS) for thousands of exons in mammalian cells. Through this system, we have analyzed global features of AS in major mouse tissues. The results provide numerous inferences for the functions of tissue-specific AS, insights into how the evolutionary history of exons can impact on their inclusion… CONTINUE READING

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