Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.

Abstract

Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary cause of hESC death following enzymatic dissociation comes… (More)
DOI: 10.1073/pnas.1002024107

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